Are we supposed to obey our pastors?

The verse that speaks the most directly to this question is Hebrews
13:17, "Obey them that have the rule over you, and submit yourselves:
for they watch for your souls, as they that must give account, that
they may do it with joy, and not with grief: for that is unprofitable
for you."

Pastors are hurt deeply to see people ignore the counsel of God they
share in messages or Bible lessons. Some people "blow off" the Word of
God, doing so not only to their own hurt but also to the hurt of those
who are around them. Young people especially have the tendency to
ignore the counsel of those older than they, making the mistake of
trusting their own wisdom as well as their own heart. God states that
a godly pastor shares precepts from God's Word because he desires not
only to serve God but to feed the flock the spiritual food that will
result in their experiencing the abundant life Jesus promised (John
10:10b).

On the other end of the spectrum, the Bible gives warning about "false
shepherds" who do not have the welfare of the flock at heart but are
more interested in maintaining control or exercising lordship over
others, or who fail to study the Word of God and end up teaching men's
commands instead of God's. The Pharisees were guilty of this during
Jesus' time. There are numerous examples of this in the prophetic
books of the Old Testament. And there are repeated warnings about this
in Acts, the epistles, and Revelation. Because of the unfortunate
existence of these self-seeking leaders, there must also come a time
when we disobey man in order to obey God (Acts 4:18-20). However,
accusations against a church leader are not to be lightly launched and
need to be substantiated by more than one witness (1 Timothy 5:19).

Godly pastors are worth their weight in gold. They are usually
overworked and underpaid. They bear greater responsibility than
medical doctors as Hebrews 13:17 states—they must one day give an
account of their ministries before God. First Peter 5:1-4 points out
that they are not dictators, but lead by their example and by their
teaching (1 Timothy 4:16) in humility of heart. And like Paul, they
are like nursing mothers who truly love their "children" and are
willing to give themselves for their flock and rule with gentleness (1
Thessalonians 2:7-12; John 10:11). They are characterized by sincere
devotion to the Word and to prayer (Acts 6:4) so that they can rule in
God's power and wisdom and impart to the flock spiritual meat to make
them healthy and vibrant Christians (1 Timothy 5:17). If this is a
description of your pastor, or close to it (no man on earth is
perfect), he is worthy of double honor and obedience as he declares
the plain teachings of God.

So the answer to the question is yes, we should obey our pastors. We
are also to pray for them always, asking God to grant them wisdom,
humility, a love for the flock, and protection as they protect those
in their care.